Uses and Properties:
Java tea is mainly used as a
diuretic in cases of chronic inflammation of the kidney and bladder and
in gall bladder catarrh, kidney catarrh, bacteriuria and irritable
bladder. The product is used on its own or in combination with tea
mixtures and urological preparations.
A diuretic is any substance that increases urination rate and therefore
increases the excretion of water. Diuretics are often used clinically along with
blood pressure medications in order to flush excess fluid and sodium from the
body to decrease the amount of fluid pumped by the heart. Furthermore, diuretics
are also used to reduce bloating and fluid retention. These effects make
diuretics useful for individuals who are undergoing weight loss and for women
who want to reduce the fluid build up that occurs during PMS. Diuretics also may
be indicated in kidney stones and gout.
Orthosiphon stamineus, otherwise known as java tea, has been used in
traditional medicine for centuries to enhance the health of the urinary system.Orthosiphon
stamineusis a popular
traditional botanical extensively used in Southeast Asia for a wide range of
conditions including rheumatism, diabetes, hypertension, tonsillitis, epilepsy,
menstrual disorders, gonorrhea, syphilis, renal calculus (kidney stones),
gallstones, edema, eruptive fever, hepatitis, and jaundice.1In
Japan, it is consumed as a healthy tea to facilitate body detoxification.1
Research confirms the traditional role of this botanical with studies showing it
has diuretic properties. Rodent studies have indicated supplementation withOrthosiphon
stamineusleads to an increase
in urine flow and increased urinary sodium excretion.2These
stamineuscan play a role in
kidney health, but its effects appear to expand to other aspects as well.
Kidney Stones and Gout
Calcium oxalate stones are the most common type of kidney stones, which can be
detected by routine x-ray studies. This type of stone is unlikely to be treated
successfully with medical therapy but certain medications may help prevent
calcium stones if they have a propensity to recur.
Kidney stones can also be caused by disordered uric acid metabolism. Uric acid
is a common constituent of urinary and renal calculi (kidney stones) and of
gouty concretions. Diuretic action is an important factor in treatment of kidney
stones of this type. An increase in the volume of fluid flowing through the
kidney will help to dissolve the stones, assisting their passing to avoid
further retention, and flushing out the deposits.
Two recent studies provide a scientific foundation for the traditional use ofOrthosiphon
stamineusin kidney stones and
stamineusappears to influence
the activity of adenosine A (1) receptor antagonists, which can protect the
kidney by increasing urine flow and sodium excretion.3
Additionally, an earlier study showed thatOrthosiphon
stamineuslowered levels of uric
acid in rodents and acted as a diuretic.4
A recent study indicates another interesting property ofOrthosiphon
stamineus. Researchers experimentally elevated body temperature in rodents
then gave themOrthosiphon
stamineus. The botanical significantly reduced the increased body
temperature. The effect persisted up to four hours following the administration
of the extract.Orthosiphon
stamineus anti-pyretic (fever-reducing) effect was comparable with that of
Anti-inflammatory and Analgesic Effects
Researchers also have studiedOrthosiphon
stamineusfor its effects on
inflammation and pain. Scientists induced edema in the hind paws of rodents.
They then gave the animalsOrthosiphon
stamineus. The botanical significantly reduced the edema 3 and 5 hours
after the swelling was induced. Furthermore,Orthosiphon
significant analgesic (pain-reducing) activity.6
According to the researchers, The results of the present study support the
and non-narcotic analgesic activities. These findings justify the traditional
use of the plant for treating pain and inflammation.
A 2007 study suggests thatOrthosiphon
stamineusmay be as protective
to the liver as it is to the kidney. Researchers treated rats withOrthosiphon
stamineusthen induced liver
toxicity in the rodents. The botanical dose-dependently reduced the necrotic
changes in the liver and inhibited the increase of serum ALT and AST activities.Orthosiphon
stamineusalso acted as a
powerful antioxidant and free radical scavenger.7
Maintaining Blood Sugar
Unlike some pharmaceutical diuretics, which are thought to increase the risk of
diabetes by promoting glucose intolerance,Orthosiphon
stamineuscan actually maintain
blood sugar levels. When the extract was given to normal and diabetic rats, it
significantly decreased plasma glucose concentration in a dose-dependent manner.
After repeated daily oral administrations of the extract for 14 days, the
extract significantly reduced plasma glucose concentration in diabetic rats at
days 7 and 14. By the end of the study, plasma triglyceride concentration was
lower in the extract-treated diabetic rats than untreated ones. Furthermore,
plasma HDL-cholesterol concentration was significantly increased in diabetic
rats treated with the extract.8
Our findings suggested thatOrthosiphon
stamineusaqueous extract is
effective for alleviating hyperglycemia and improving lipid profile in diabetic
rats, the researchers wrote.
Balancing Nitric Oxide Levels
Nitric oxide (NO) is an important molecule that signals the blood vessels to
relax and acts in many tissues to regulate a diverse range of physiological
processes. When certain cells are activated by specific proinflammatory agents
such as endotoxins, tumor necrosis factor (TNF), interferon-gamma (IFN-g), and
interleukin-1 (IL-1), NO is produced and protects the host by damaging
pathogenic DNA. Balanced amounts of nitric oxide are essential to optimal health
because just as normal amounts of NO promote health, the excessive production of
NO that can occur during the inflammatory process can have detrimental effects
on many organ systems of the body, which can lead to tissue damage. Therefore,
inhibiting NO accumulation by inflammatory stimuli can result in overall
Orthosiphon stamineushas been
shown to inhibit levels of nitric oxide in macrophages that were stimulated with
inflammatory endotoxins, indicating that the botanical can help support healthy
levels of nitric oxide and reduce one of the harmful effects of inflammation.1
The diuretic botanicalOrthosiphon
stamineushas been extensively
studied in rodents with no signs of toxicity. In a 2008 study, researchers
administered the botanical orally to rats for 14 days and compared it to a
control group receiving distilled water. The four test groups were treated with
0.5 g/kg, 1 g/kg, 3 g/kg and 5 g/kg body weight ofO.
lethality or adverse toxic signs were seen during the experimental period.9
According to the researchers, In conclusion, methanol extract ofO.
stamineuswithin these range and
treatment duration would not cause any severe toxic effects and organ damage in
Individuals in Malaysia, Vietnam and Japan have consumedOrthosiphon
stamineusfor centuries, further
supporting its safety.
Orthosiphon stamineus, which is found in the new product Herbal Diuretic
along with 99 mg of potassium, is a natural diuretic supplement that can support
kidney and liver health, reduce the excessive fluid retention that occurs during
PMS, alleviate bloating, promote sodium excretion and act as an
anti-inflammatory and analgesic agent. For individuals seeking diuretic support,
it is an excellent choice that can also maintain liver health and blood sugar.
1. Awale S, Tezuka Y, Banskota AH, Siphonols KS. Novel Nitric Oxide Inhibitors
from Orthosiphon stamineus of Indonesia. Bioorganic & Medicinal Chemistry
2. Beaux D, Fleurentin J, Mortier F. Effect of extracts of Orthosiphon stamineus
Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi
(L.) Spreng. in rats. Phytother Res. 1999 May;13(3):222-5.
3. .Yuliana ND, Khatib A, Link-Struensee AM, Ijzerman AP, Rungkat-Zakaria F,
Choi YH, Verpoorte R. Adenosine A1 receptor binding activity of methoxy
flavonoids from Orthosiphon stamineus. Planta Med. 2009 Feb;75(2):132-6.
4. Arafat OM, Tham SY, Sadikun A, Zhari I, Haughton PJ, Asmawi MZ. Studies on
diuretic and hypouricemic effects of Orthosiphon stamineus methanol extracts in
rats. J Ethnopharmacol. 2008 Aug 13;118(3):354-60.
5. Yam MF, Ang LF, Basir R, Salman IM, Ameer OZ, Asmawi MZ. Evaluation of the
anti-pyretic potential of Orthosiphon stamineus Benth standardized extract.
Inflammopharmacology. 2009 Feb;17(1):50-4.
6. Yam MF, Asmawi MZ, Basir R. An investigation of the anti-inflammatory and
analgesic effects of Orthosiphon stamineus leaf extract. J Med Food. 2008.
7. Yam MF, Basir R, Asmawi MZ, Ismail Z. Antioxidant and hepatoprotective
effects of Orthosiphon stamineus Benth. standardized extract. Am J Chin Med.
8. Sriplang K, Adisakwattana S, Rungsipipat A, Yibchok-Anun S. Effects of
Orthosiphon stamineus aqueous extract on plasma glucose concentration and lipid
profile in normal and streptozotocin-induced diabetic rats. J Ethnopharmacol.
2007 Feb 12;109(3):510-4.
9. Chin JH, Abas HH, Sabariah I. Toxicity study of Orthosiphon stamineus Benth (Misai
Kucing) on Sprague Dawley rats. Trop Biomed. 2008 Apr;25(1):9-16.